Equipment & Facilities
Following is a list of key items of equipment/instrumentation available at the PMBRC.
Material Characterisation
- X-ray Diffractometer (XRD), with non-ambient capability – Bruker D8 Advance
- Particle Size Analyser (Laser Diffraction) – Malvern Instruments Mastersizer 2000 (Liquid & Powder Units)
- Particle Size Analyser (Dynamic Light Scattering) – Microtrac, Nanotrac Wave II
- BET Surface Area & Pore Size Analyser – Micromeritics Gemini VI
- Differential Scanning Calorimeter (DSC) – NETZSCH DSC214 polyma & TA Instruments Q2000
- Thermal Gravimetric Analyser (TGA) – TA Instruments Q50
- Surface Tension & Contact Angle Measurement System – Krüss G10
- Texture Analyser – Stable Micro Systems, TA.XTplus
- Dynamic Vapour Sorption (DVS) – Surface Measurement Systems, DVS Intrinsic
- Powder Rheometer – Freeman Technology FT4
- Fluid Rheometer – TA Instruments ARG2
Chromatography & Mass Spectrometry
- LC/MS System – Agilent 1200 Series / XCT Ultra Ion-Trap MS Detector, with HPLC-Chip
- LC/MS System – Agilent 1260 Infinity II Series / 6545 LC/Q-TOF MS Detector
- Rapid Resolution LC Systems – Agilent 1200 Series, with Photodiode Array, Refractive Index and Fluorescence Detection
- Ion Chromatography System – Thermo Scientific, Dionex ICS-5000
- Supercritical Fluid Chromatography (SFC) System – Waters, Acuity UPC2 CO2
- GC/MS System (Ion Trap) – Varian 450-GC / 220-MS, with specialist Programmable Solids Probe, SPME and Headspace Accessories
- GC/MS System (Single Quadrupole) – Thermo, Focus GC & DSQ MS
- GC/FID System – Hewlett Packard, 6890 Series
- Capillary Electrophoresis (CE) System – Agilent CE G1600AX
Spectroscopy
- 400 MHz NMR System, including Solid State Probe – Joel ECX-400
- FTIR Spectrometer, with Microscope – Varian 660-IR & 610-IR
- FTIR Spectrometer, with UATR Accessory – PerkinElmer Spectrum Two FT-IR Spectrometer
- NIR Spectrometer – ThermoScientific ANTARIS II FT-NIR Analyser
- ICP-Optical Emission Spectrometer – Varian 710-ES
- UV Spectrometer – Shimadzu UV-2401PC
- Fluorescence Spectrometer – Varian CARY Eclipse
- Ultra-Low Light Level Spectrometer – Princeton Instruments
- Benchtop Scanning Electron Microscope (SEM), with Energy Dispersive X-ray Spectroscopy (EDX) – TM4000 Hitachi Technologies
Microscopy
- Benchtop Scanning Electron Microscope (SEM), with Energy Dispersive X-ray Spectroscopy (EDX) – TM4000 Hitachi Technologies
- Atomic Force Microscope (AFM) – Bruker Dimension Icon (Glovebox mounted), with the following modes: Contact (liquid/ambient), Tapping (liquid/ambient), Peak Force, Torsional Resonance AFM, Peak Force Kelvin Probe, Peak Force Tunnelling, Tunnelling AFM, Peak Force Quantitative Nanomechanical Mapping, Conductive AFM, Photoconductive AFM, Scanning Tunnelling Microscopy (STM)
- Fluorescence Microscope – Olympus BX51
- Optical Microscopy – Wide range of optical microscopes available at the PMBRC
Formulation / Pre-formulation
- Spray Dryer – ProCepT 4M8-TriX
- Fluid Bed Processing (Drying/Granulating/Coating) – GEA Strea 1 Classic
- Rotary Tablet Press – Riva Piccola 8-station, D-type Tooling
- Manual Tablet Press – GlobePharma MTCM-I
- Freeze Dryer – LABCONCO, Freezone 2.5
- Dissolution Bath – (1.) Distek Dissolution System 2100C; (2.) Vankel/Varian Systems
- Disintegration Bath – PharmaTest, Dist 3
- Hardness, Bulk/Tap Density and Friability Testers
- Polymer Twin-Screw Extrusion System (with Supercritical CO2 Capability) – SCF Processing Ltd.
- Y-Blender – ERWEKA AR 403, with Y5 Mixing Vessel
Molecular Biotechnology
- Protein Analysis System – (1.) iBind2 Western Blotting; (2.) Bolt & Novex native PAGE Electrophoresis Systems
- Real-Time PCR System – Applied Biosystems 7300
- Pulsed Field Gel Electrophoresis (PFGE) System – BioRad CHEF-DR II
- UV-Vis Spectrophotometer (220-750nm) – Nanodrop ND-1000
- Thermal Cyclers – Applied Biosystems 2720
- Roche Hybridisation Oven
- Syngene GeneGenius Bioimaging System
Biomedical
- Flow Cytometer – Beckman Coulter Cytomics FC 500
- Suspension Multi-Array System – BIO-RAD Bio-Plex 200
- Enzyme-Linked ImmunoSorbent Assay (ELISA)
- Haematology Analyser – Beckman Coulter Ac.T diff
- Clinical Chemistry Analyser
- HTS Plate Reader – MSD Model 1250 Sector Imager
General
- Environmental Chamber (Temp & RH) – Memmert HPP 110
- Ovens – Memmert UF260
- Microwave Digester – CEM, MARS 6
- Karl Fischer (Water Determination) – Metrohm 701 KF Titrino & 703 Ti Stand
- Rotary Pumped Coater (Sputtering & Carbon Coating) – Quorum Q150R ES plus
Lithography
- Aerosol Jet Printer – Optomec AJ300
- Nanolithography System – Eulitha PHABLE
- Thin Film Vacuum Coating System – Edwards AUTO 306
- Plasmonic Sensor Characterisation Suite – Hamamatsu Opto-Spectrum Generator (OSG); ANDOR ICON charge-coupled device (ccd) camera; ANDOR complementary metal-oxide semiconductor (CMOS) camera
- Spin-coater – Laurell WS 400B